Three studentships on anthelmintic control in sheep
Project number: 73102
- Dr Philip Skuce, Moredun Institute
- Dr John Gilleard, Glasgow University
- Prof. Peter Brophy, IRS & Prof. Huw Rees, University of Liverpool
Partners: HCC, QMS
Parasitic nematodes represent one of the most serious animal health problems of grazing livestock in the UK causing significant economic loss and animal welfare problems. Gastrointestinal nematode infections alone cost the UK sheep industry £65 million per annum.
There is a need to understand how the genetics of worms are changing, as control strategies need to consider how resistance is transmitted. These three PhD studentships are looking at molecular markers and changes in gene expression that could be used to diagnose and monitor anthelmintic resistance. Each one is approaching the problem from a different aspect, but the results from each individual project will feed into the others.
- To identify the mutations conferring ivermectin resistance to Haemonchus contortus
- To identify markers for monitoring resistance in Haemonchus contortus and Teladorsagia circumcincta
- To investigate how anthelmintic resistant Teladorsagia circumcincta deals with the wormers (metabolism/excretion)
Molecular genetic techniques will be applied to various populations of worms to address the projects‘ objectives.
The results from these studentships will increase the knowledge on anthelmintic resistance, and will feed into current or planned projects.